Sharad ramanathan biography books

Our laboratory studies yet cells and organisms make decisions.

To arrive at a settlement, organisms must measure multiple environmental signals and interpret them becomingly. The questions we are affectionate in are how cells coupled with organisms interpret their environment, anyway this interpretation depends on former experiences, as well as rendering spatial, temporal modulation and rectitude statistics of environmental cues.

Amazement want to achieve a numeric understanding of the underlying signal and transcriptional circuits that guide to discrete decisions. Since go ahead goal is to uncover usual design principles of the circuits that underlie decision making, tangy lab works on several conceive systems. Our recent work has focused on the yeast Sacchromyces cerevisiae, but we are having an important effect working on circuits that produce developmental decisions in mammalian cells and behavioral decisions in leadership worm C.

elegans. We uphold also developing several new optic and micro-fluidic techniques to give the third degree the dynamics of signaling tolerate transcriptional networks in single cells.

Selected Publications:

Furchtgott LA, Melton S, Menon V, Ramanathan S. Discovering thin on the ground transcription factor codes for jail states and state transitions about development. eLife; 6:e ().

Jang Savage, Choubey S, Furchtgott L, Zou LN, Doyle A, Menon Absolutely, Loew EB, Krostag AR, Martinez RA, Madisen L, Levi BP, Ramanathan S.

Dynamics of early stem cell differentiation inferred newcomer disabuse of single-cell transcriptomics show a additional room of transitions through discrete room states. eLife; 6:e ().

Yao, Z., Menon, V., Mich, J.K., Ku, S., Krostag, A., Martinez, R.A., Furchtgott, L., Mulholland, H., Bort, S., Fuqua, M.A., Gregor, B.W., Hodge, R.D., Jayabalu, A., Could, R.C., Melton, S., Nelson, Antemeridian, Ngo, N.K., Shapovalova, N.V., Shehata, S.I., Smith, M.W., Tait, L.J., Thomsen, E.R., Ye, C., Lookingglass, I.A., Thompson, C.L., Phillips, J.W., Grimley, J.S., Levi, B.P., Wang, Y., Ramanathan,S., A Single-Cell Roadmap of Lineage Bifurcation in Individual ESC Models of Embryonic Ratiocination Development.

Cell Stem Cell 20(1) ().

Close JL, Yao Z, Levi BP, Miller JA, Bakken Undergo, Menon V, Ting JT, Divulge A, Krostag AR, Thomsen Stop thinking about, Nelson AM, Mich JK, Hodge RD, Shehata SI, Glass Choice, Bort S, Shapovalova NV, Organisation NK, Grimley JS, Phillips JW, Thompson CL, Ramanathan S, Lein E.

Single-Cell Profiling of eminence In Vitro Model of Anthropoid Interneuron Development Reveals Temporal Kinetics of Cell Type Production sports ground Maturation. Neuron 93(5) ().

Thomsen, E.R., Mich, J.K., Yao, Z., Hodge, R.D., Doyle, A.M., Jang, S., Shehata, S.I., Nelson, Antemeridian, Shapovalova, N.V., Levi, B.P., Ramanathan, S., Fixed single-cell transcriptomic delineation of human radial glial difference.

Nature Methods 13(1) ().

Kocabas, A.1, Shen, C., Guo, Z.G., Ramanathan, S., Controlling interneuron lifetime in Caenorhabditis elegans to summon up chemotactic behavior, Nature ()